In particular, CXCR3 expression was reduced on unswitched CD27intIgD+ memory B cells (area 3) in individuals with long-standing diabetes vs healthy donors (p < 0.01 in Study A, p < 0.01 in Study B), CD45R/B220 expression was reduced on both unswitched CD27intIgD+ memory B cells (area 3: p < 0.005 in Study A, p < 0.005 in Study B) and naive CD27−IgD+ B cells (area 4: p < 0.05 in Study A, p < 0.005 in Study B), and CD95 expression was reduced on switched CD27+IgD− memory B cells (area 7: p < 0.05 in Study A, p < 0.01 in Study B). Here, FAS is linked to diabetes mellitus.