Syndecan (SDC) is a member of heparan sulfate proteoglycan (HSPG) family, where SDC-1 promote cancer cell proliferation (Maeda et al., 2004; Baba et al., 2006) and integrin-mediated binding for cell adhesion and migration (Beauvais and Rapraeger, 2003). This evidence concerns the gene CD44 and cancer.