The most well-researched glypican is GPC-3, specifically for its tumor suppressor effects by inhibiting Insulin-like GF (IGF)/Wnt (Wingless-type MMTV integration site family) signaling and phosphoinositide 3-kinase (PI3K)/AKT signaling (Buchanan et al., 2010). The gene discussed is IGF1; the disease is neoplasm.