Activation of cells in the adjacent stroma (endothelial cells, cancer-associated fibroblasts, pericytes, and leukocytes) via paracrine signaling with pro-tumorigenic factors (transforming growth factor beta, hepatocyte growth factor, epidermal growth factor, fibroblast growth factor, and IL-6) sustain tumor growth, enhancing genomic instability and epigenetic dysregulation (8, 13, 14). Here, IL6 is linked to cancer.