When a breast cancer metastasis is suspected, the expression of hormonal receptors [estrogen receptors (ERs) and progesterone receptors (PgR)] must be investigated, although their expression is not specific as observed in ovarian, endometrial adenocarcinomas, and bronchopulmonary adenocarcinomas (47, 49). The gene discussed is NR4A1; the disease is endometrium adenocarcinoma.