Moreover, siPLK1-IONPs were conjugated to membrane translocation peptide (myristoylated polyarginine peptides (MPAP)) for driving endosomal escape and mediating transport to the cytoplasm and a tumor-selective peptide underglycosylated MUC1 (uMUC1)-specific peptide (EPPT1) to increase intracellular and tumor-specific delivery. Here, MUC1 is linked to neoplasm.