This latest report brings the total number of MS risk associations to 233, including 200 autosomal variants outside the MHC, one on the X chromosome and 32 independent effects in the broader MHC locus, covering both classical and nonclassical gene regions.46 Again, careful pathway, transcriptomic and epigenetic enrichment analyses suggest T‐cell biology is a major feature of the disease, but also highlight the involvement of many other components of both adaptive and innate immunity in pathogenesis. Here, HLA-C is linked to myeloid sarcoma.