Eicosapentaenoic acid stimulation enhances the effects of MSC therapy in experimental allergic asthma, leading to increased secretion of pro-resolution and anti-inflammatory mediators, modulation of macrophages toward an anti-inflammatory phenotype, and reductions in elastic and collagen fiber content, α-SMA expression, and mucin-containing cell counts. The gene discussed is MUC5AC; the disease is allergic asthma.