Here again, a potential involvement of Gasdermin D needs to be better studied in our model, since Kambara et al. (55) showed that Gasdermin D deficiency unexpectedly and paradoxically augments host defenses against extracellular E. coli by delaying neutrophil death and by the increase in the host bactericidal activity to E. coli infection. Here, GSDMD is linked to escherichia coli infection.