non-obese diabetic (NOD) mice manifest not only type I diabetes (T1D) but SjS-like autoimmune endocrinopathy as well and also present a few hallmark autoantibodies like ANA, anti-SSA/Ro, anti-SSB/La, anti-a-fodrin, etc. (3–5). The gene discussed is CALR; the disease is type 1 diabetes mellitus.