IL1B and Decreased total neutrophil count: To note, using a zebrafish model of local Shigella infection to perturb the cytoskeletal septins proteins expression, we recently reported deregulated inflammatory response and neutropenia and showed that too much IL1β-dependent inflammation resulted in the increased susceptibility of neutrophils to Shigella infection, with concomitant death of the engulfing neutrophils (36).