ACE and diabetes mellitus: For example, in a study involved the use of Wistar rats in which diabetes was induced by streptozotocin administration, and the animals were additionally challenged by a subcutaneous administration of angiotensin II to induce hypertension, a prolonged administration of pomegranate juice (for 4 weeks) reduced activity of angiotensin converting enzyme (ACE), as well as decreased mean arterial blood pressure in comparison with non-treated animals (Mohan et al., 2010).