Furthermore, it is noteworthy that most of the DN model rats did not exhibit a mass of proteinuria, renal dysfunction and the typical glomerular sclerosis marked by the severe collagen accumulation and the significant stainings of FN and Col-I in glomeruli, which are the recognized glomerular damaged features in the middle and advanced stages of DN. The gene discussed is FN1; the disease is Glomerular sclerosis.