RPS6KB1 and Hyperglycemia: Sakaguchi et al. reported that rapamycin (RAP), a specific inhibitor of mTORC1 signaling, can attenuate renal enlargement and the enhanced phosphorylation of p70S6K in the kidneys of the early diabetic mice, suggesting the activation of PI3K/Akt/mTOR signaling and the phosphorylation level of p70S6K might play an important role in renal hypertrophy under hyperglycemia (Sakaguchi et al., 2006).