For example, the variant rs3775444 in the SNCA (a-synuclein) gene, a well-established susceptibility gene in PD (Chen Y. et al., 2015), and H1 haplotype of the MAPT (microtubule-associated protein tau) gene, another well-known risk factor for PD (Sailer et al., 2016), have shown evidence of association with MSA. Here, SNCA is linked to multiple system atrophy.