Consistently, we found the patients carrying with allele “A” was related with higher plasma NOD2 compared with patients carrying with allele “G.” Therefore, in our study, we speculated a potential pathogenic role of rs3135500 in MSA is through the alteration of miRNA-mRNA binding, which could result in increased NOD2 expression and chronic inflammation activity in the patients carrying the “A” allele of rs3135500. The gene discussed is NOD2; the disease is multiple system atrophy.