NOD2 and colorectal carcinoma: Additionally, a miRNA-binding variant in the 3′-UTR of the NOD2 gene, rs3135500, which may modify miRNA-mRNA binding and alter target gene regulation, was reported to be related to another gastrointestinal tract disease in which inflammatory is an important risk factor, colorectal cancer (CRC), in Iranian (Ahangari et al., 2014).