When compared to MBs arising in mouse and human WNT, SHH and two Retro-Myc G3 MB mouse models, the CRISPR-Myc tumors shared cardinal properties with Retro-Myc G3 tumors, including large cell anaplastic features (Fig. 2c) and canonical histological markers (Fig. 2d). The gene discussed is SHH; the disease is Mobius syndrome.