CDK6 and neoplasm: Thus, miR-16 is generally thought to be a key tumor-suppressive miRNA, and many studies have shown that miR-16 can modulate the cell cycle, inhibit cell proliferation, attenuate cell invasion, promote cell apoptosis and suppress tumorigenesis by targeting B-cell lymphoma 2 (Bcl-2), CCND1 (cyclin D1), CCND3 (cyclin D3), CCNE1 (cyclin E1), CDK6 (cyclin-dependent kinase 6) and WNT3A (wingless-type MMTV integration site family, member 3A) in various cancers21, 29–31.