PDE4D and neurodevelopmental disorder: To prioritise variants, we combined information across linkage analyses in the t(1;11) family, brain cis-eQTLs, and association in two UK population-based cohorts and identified consistent, although nominal, evidence of association between variants in GRM5, PDE4D and CNTN5. All three genes have previously been associated with psychiatric or neurodevelopmental disorders (Supplementary Information: GRM5, PDE4D and CNTN5).