PDE4D and major depressive disorder: Although these cross-trait associations are in some cases within the same subregion, as defined by the recombination rates across the region in the 1000 Genome UK population, for example, for affective disorder, cognitive variable and number of episodes in CNTN5 (Supplementary Figure 7c), or affective disorder, MDD and Mill Hill vocabulary in PDE4D (Supplementary Figure 7d), this is not true for affective disorder and psychological distress in CNTN5 (Supplementary Figure 7c), or affective disorder and MDD in chr4q (Supplementary Figure 8d).