DISC1 and psychiatric disorder: We do not rule out the influence of differential environmental exposures on psychiatric outcome, but our study clearly indicates that the high density of psychiatric disorder in the t(1;11) family involves a combination of: direct effects of the translocation on the genes located at the breakpoint (DISC1, DISC2, DISC1FP), the “locking together” of familial risk factors, additional unlinked loci and common risk variants.