The increased expression of RIP1 was important for survival of melanoma cells that acquired resistance to BRAF inhibitors, in that RIP1 silencing by siRNA along caused reduction in cell viability in Mel-CV.S and Mel-RMu.S cells and in post-treatment fresh melanoma isolates, and re-sensitized these cells to PLX4720-induced cell death (Fig. 2c, d). Here, BRAF is linked to melanoma.