As shown in Fig. 5a, combined silencing of ERK1 and ERK2 resulted in reduction in RIP1 expression not only in Mel-CV.S and Mel-RMu.S cells, but also in Mel-CV and Mel-RMu cells, indicating that ERK1/2 signaling promotes RIP1 expression in melanoma cells. This evidence concerns the gene RIPK1 and melanoma.