Moreover, protection of melanoma cells against apoptosis by RIP1 appeared to be mediated by NF-κB activity, in that hyperactivation of NF-κB diminished enhancement in apoptosis caused by RIP1 silencing, whereas genetic or pharmacological inhibition of NF-κB recapitulated the sensitizing effect of RIP1 silencing on induction of apoptosis. This evidence concerns the gene RIPK1 and melanoma.