RIPK1 and melanoma: The functional significance of NF-κB in RIP1-mediated protection of melanoma cells from PLX4720 was demonstrated by silencing of IκBα with siRNA, which caused hyperactivation of NF-κB and abolished killing of Mel-CV.S and Mel-RMu.S cells by RIP1 silencing with or without the addition of PLX4720 (Fig. 3f, g)20.