AGER and cancer: The greater magnitude of the effects of rh Ac-APE1/Ref-1 but not rh APE1/Ref-1 on cell viability and DNA fragmentation in RAGEOV cells than in RAGEKD cells indicates that rh Ac-APE1/Ref-1 has a promising role as a triggering molecule to initiate RAGE-mediated cancer cell death signaling (Fig. 8B).