Together, HuR was found to enhance the methylation of TERC, in turn promoting the assembly of the TERC/hTERT complex and elevating telomerase activity; TERC-bearing mutations linked to DC, aplastic anemia, or autosomal dominant DC disabled TERC methylation (U100A, G107U, and GC107/108AG) or its association with HuR (U100A). Here, ELAVL1 is linked to aplastic anemia.