Levels of ALT and AST in the PPVAL + ISS group at 48 h after surgery were still significantly higher when comparing with PPVL + ISS group and PVL group (p < 0.05); meanwhile, levels of ALT and AST in the PPVL + ISS group were obviously lower than those in the PVL group (p < 0.05). The gene discussed is GPT; the disease is periventricular leukomalacia.