Here we used Sertoli and germ cell–specific disruption of Lrrc8a to show that the male infertility observed in Lrrc8a−/− mice and ébouriffé mice (28, 29), which express severely truncated LRRC8A proteins (30), is due to a loss of VRAC in germ cells. The gene discussed is LRRC8A; the disease is male infertility.