LMO2 and acute lymphoblastic leukemia: Rosa26‐Lmo2 + Sca1‐Cre mice had a shorter lifespan than their wild‐type (WT) littermates [Fig 1A; P < 0.0001; log‐rank (Mantel–Cox) test] due to the development of T‐ALL (96.7%; 30/31) that manifested as thymoma, splenomegaly, and disrupted thymic, liver, and splenic architectures (Fig 1B; Appendix Fig S3A and B).