SHH and medulloblastoma: A similar analysis for each medulloblastoma subgroup showed that group 4 tumors demonstrate the lowest concordance (Fig. 2b and Additional file 3: Figure S1b), with a Spearman correlation mean of 0.16 compared to 0.30, 0.24, and 0.21 for group 3, SHH, and WNT respectively (four group comparison, Kruskal-Wallis test, p-value < 2.2e− 16).