NF1 and ganglioglioma: This study reveals that ganglioglioma is genetically defined by alterations that activate the MAP kinase signaling pathway in the vast majority of cases, either via BRAF p.V600E mutation or a spectrum of other genetic alterations including alternative BRAF mutations or fusions, RAF1 fusion, KRAS mutation, NF1 mutation, or FGFR mutations or fusions.