The activating p.V600E hotspot mutation in the BRAF oncogene has been identified in a subset of gangliogliomas, ranging from approximately 10–60% depending on the study and anatomic site, with highest frequencies reported in cortical tumors and lower frequency reported in spinal cord tumors [6, 7, 9, 11–13, 16, 21, 27, 30, 31, 36–38]. Here, BRAF is linked to ganglioglioma.