Four of the gangliogliomas in this cohort harbored recurrent small in-frame insertions at codon 505 or 506 in the β3-αC loop in the kinase domain of BRAF (p.L505delinsLEYLS, p.R506delinsRVLR [in two cases], and p.R506delinsRSTQ). The gene discussed is BRAF; the disease is ganglioglioma.