PDE4DIP and breast cancer: Additional functional annotation analysis using the Jensen disease library, showed that the top significant genes involved in breast cancer are KATB6, PDE4DIP, MXRA5, DNHA3 and NBPF10. KAT6B—a histone acetyl transferase involved in DNA replication, gene expression and regulation, and epigenetic modification of chromosomal structure [50] has been reported as associated with breast cancer in two separate WES studies [19, 20].