The genes APP, SGSM1, ROR1, PDGFRB, GRIN3A, SEZ6L, NCOR1, FSHR, SLC22A2, TBC1D32, OCA2, and ASAH1, which also encompassed nsSNPs, were classified into Alzheimer’s disease after reference to the GAD. This evidence concerns the gene SLC22A2 and early-onset autosomal dominant Alzheimer disease.