This idea is strengthened by several studies that have found a correlation between CtBP1/2 overexpression and cancer progression in multiple tumor types, including blood (Senyuk et al., 2002), skin (Deng et al., 2013), breast (Birts et al., 2010; Deng et al., 2012; Di et al., 2013), prostate (Moiola et al., 2014; Wang et al., 2012), ovarian (May et al., 2013; Zhang et al., 2017), and colon cancers (Pena et al., 2005, 2006). This evidence concerns the gene CTBP1 and neoplasm.