A second-line therapy, involving combination treatment with ramucirumab (RAM), an anti-vascular endothelial growth factor receptor-2 (VEGFR-2) monoclonal antibody, and solvent-paclitaxel (PTX), also improves overall survival (OS) [5], on the basis of the beneficial outcomes of a global phase III trial and is currently commonly employed as the second-line regimen for patients with GC [6]. Here, KDR is linked to gastric cancer.