In particular, previous studies by Liong et al. and Hitti et al. that used the proteomic and cohort approaches have shown significantly increased expression of CVF VDBP in association with the occurrence of impending PPROM in asymptomatic women and of SPTD and intra-amniotic infection in women presenting with symptoms of PTL [11, 13–15]. This evidence concerns the gene GC and chorioamnionitis.