In the subgroup of women without intra-amniotic infection, the CVF VDBP levels were significantly higher in women with PPROM than in those with PTL (mean ± SD: 2.20 ± 1.69 μg/mL vs. 1.232 ± 1.45 μg/mL, P < 0.001). The gene discussed is PNLIP; the disease is preterm premature rupture of the membranes.