Significant genetic correlations were identified between self-reported tiredness and psychological/psychopathological traits (e.g., major depressive disorder, bipolar disorder, schizophrenia, verbal-numerical reasoning, and neuroticism), as well as various biomedical and health behavior indices (e.g., body mass index [BMI], C-reactive protein, forced expiratory volume, smoking status, and triglycerides). The gene discussed is CRP; the disease is schizophrenia.