On the other hand, double-deficient mdx/utrn-/- mice have a lower body weight, widespread muscular fibrosis and necrosis, a reduced lifespan, spinal deformity, joint contractures, and earlier symptoms of cardiomyopathy than their mdx/utrn+/+ and mdx/utrn+/- counterparts [7,28,30–35]. Here, UTRN is linked to cardiomyopathy.