Seven key genetic variants, rs6545816 and rs1427407 (BCL11A), rs9376090, rs66650371, rs9402686 and rs6920211 (HBS1L-MYB) and rs7482144 (XmnI-HBG2) were genotyped in 260 Nigerian SCA patients (summary data shown in Table 1) and their effects on HbF levels and other haematological parameters were investigated. The gene discussed is MYB; the disease is autosomal dominant cerebellar ataxia.