ACKR1 and malaria: The T to C transition, also referred to as FY-null allele, results in the disruption of a GATA motif (Fig 5D) and subsequently the loss of erythrocyte cell surface expression of Duffy blood group antigen, a mechanism to resist erythrocyte invasion by the human malaria parasites Plasmodium vivax and P. Knowles into red blood cells [15].