EZH2 and diffuse large B-cell lymphoma: Follicular and diffuse large B-cell lymphomas harboring activating mutations in the HMT EZH2, the enzymatic component of polycomb repressive complex 2 (PRC2) [61], are good candidates for EZH2-targeted therapies using pharmacological inhibitors (EZH2i), such as GSK126, already shown to have antiproliferative activity in vitro and in EZH2 mutant models in vivo [13].