These factors include IL-6, PDGF, platelet factor 4, and vascular endothelial growth factor.[9,35,36] Recently, several studies have also presented data that suggest that the interaction between platelets and cancer is reciprocal and that cancer cells might first simulate platelet activity and production, and then platelets might promote tumor growth, invasion, and metastasis.[5]. This evidence concerns the gene IL6 and neoplasm.