By combining the HRs and 95%CIs from primary studies, we showed that elevated CD133 expression was associated with poor OS (HR = 2.01; 95%CI = 1.50–2.70, P < .001) and poor DFS (HR = 2.21; 95%CI = 1.75–2.81, P < .001) in CRC. Here, PROM1 is linked to colorectal carcinoma.