Among the various markers, CD133 is one of the most robust surface marker of CSCs in CRC.[6] It is widely expressed in numerous types of solid tumors, involving CRC.[7] As a 5 transmembrane single-chain glycoprotein, CD133, with a molecular weight of 120 kDa, was first found to be expressed in hematopoietic stem and progenitor cells by Yin et al.[8] Also the exploration of CD133 as a surface marker of colon cancer stem cells is still in progress. Here, PROM1 is linked to malignant colon neoplasm.