NPC1 and nasopharyngeal carcinoma: The most well characterized murine model of NP-C (Npc1−/−, BALB/cNctr-Npc1m1N/J) carries a spontaneous mutation in the Npc1 gene (6) and exhibits classical NP-C neurological symptoms and pathology from 6 weeks of age that mimic the human disease including tremor, weight loss and ataxic gait.