In an important way, deficits in the postsynaptic density protein 95 (PSD‐95) were observed in hippocampal synaptosomes in 3xTg‐AD compared to Ntg mice, supporting the idea that alterations in postsynaptic structures may occur in 3xTg‐AD mice (Figure 3a,b). The gene discussed is DLG4; the disease is Alzheimer disease.