In addition, overexpression of active PAK prevents the drebrin loss induced by soluble Aβ1‐42 oligomers, whereas pharmacological PAK inhibition in 3xTg‐AD mice leads to drebrin loss as well as memory impairments in adult mice (Arsenault et al., 2013; Zhao et al., 2006). This evidence concerns the gene DBN1 and Alzheimer disease.