In agreement with these previous reports, the current study shows that the synaptic deficits observed in 3xTg‐AD mice at this early stage of the disease occur before the accumulation of plaques and tangles, suggesting that soluble oligomeric Aβ and phospho‐tau isoforms can induce profound synaptic deficits in 3xTg‐AD mice by 7‐8 months of age. The gene discussed is MAPT; the disease is Alzheimer disease.