MAPT and Alzheimer disease: We further evaluated tau pathology in Ntg and 3xTg‐AD synaptosomes, and western blot analysis showed significant accumulation of total tau in 3xTg‐AD mice compared to Ntg mice, due in part to the presence of both endogenous and human tau in 3xTg‐AD mice (Baglietto‐Vargas et al., 2014) (Figure 5g,h).