HSPD1 and autoimmune disease: Hsp65 of Mycobacterium tuberculosis is highly homologous to human hsp60 (33), and it is not clear whether hsp60 autoantibody in many clinical diseases such as cancer, and autoimmune diseases are the result of cross reactivity to hsp65 of mycobacteria, since mycobacteria, pathogenic or non-pathogenic, are abundant in the environment (27, 33).