VWF and Decreased liver function: These patients have increased risk of thrombosis due to CVCs, as well as acquired thrombophilia secondary to inflammation [including both the elevation of pro-coagulant acute phase reactant proteins such as fibrinogen, factor VIII, and/or von Willebrand factor (VWF), as well as the suppression of protein S by inflammation-related C4B binding protein], or natural anticoagulant protein deficiencies due to vitamin K deficiency and/or liver dysfunction (6).