TF and Sepsis: There is significant interplay between inflammation and coagulation in sepsis, highlighted by the procoagulant properties of the endothelium such as expression of tissue factor (TF) and VWF, activating interactions with platelets, release of procoagulant microparticles, and downregulation of TF pathway inhibitor (TFPI) and the protein C/S anticoagulant system, inhibiting fibrinolysis.