A recent cohort of 268 adults with incident VTE events over 4.6 years from the Reasons for Geographic And Racial Differences (REGARDS) cohort demonstrated that higher CRP levels and lower serum albumin levels were associated with increased VTE risk and statistically mediated part of the association of body mass index (BMI) with VTE, suggesting that inflammation may be a potential mechanism underlying the relationship between obesity and VTE risk. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.