Previous studies have shown involvement of the thalamus in patients with ALS without FTD (e.g. in C9orf72-ALS: Bede et al., 2013) and it will be useful to study the FTD/MND continuum further in larger cohorts, given the relatively limited size of the FTD-MND group in this study. Here, C9orf72 is linked to amyotrophic lateral sclerosis.