NGF and early-onset autosomal dominant Alzheimer disease: The observed high uptake into astrocytes could have potential for treating reactive gliosis occurring in brain traumata, multiple sclerosis and Alzheimer's disease, by loading DSA with nerve growth factor (NGF) as NGF has been already shown to be antigliosis and neuroprotective.58 Nonetheless, brain targeted chemotherapeutics may also represent a possible suitable drug cargo for glioma or brain tumor in general.