TET2 and malignant colon neoplasm: Accordingly, MC2884 was able to induce an apoptotic response in Tet2−/− APL murine cells, a mouse model for aggressive human APL (Figure 5C), and in HCT116-p53−/− colon cancer cells (Figure 5D), which also displays a very aggressive behavior, suggesting MC2884 therapeutic potential also for TP53 or TET2-deficient human cancers.