Excitingly, both TP53−/− colon cancer and Tet2−/− APL cells, which show a highly aggressive behavior [40–42], displayed high sensitivity to MC2884, suggesting that as a consequence of the MC2884-mediated induction of hypoacetylation, patients with aggressive cancer phenotypes (that may be in an overall hyperacetylated state) might benefit from this type of approach. This evidence concerns the gene TP53 and colonic neoplasm.