Excitingly, both TP53−/− colon cancer and Tet2−/− APL cells, which show a highly aggressive behavior [40–42], displayed high sensitivity to MC2884, suggesting that as a consequence of the MC2884-mediated induction of hypoacetylation, patients with aggressive cancer phenotypes (that may be in an overall hyperacetylated state) might benefit from this type of approach. The gene discussed is TP53; the disease is acute promyelocytic leukemia.