In line with these binding data, the monovalent α-EGFR TM stimulates UniCAR T cells only to attack tumor cells expressing high levels of EGFR, while the bivalent α-EGFR-EGFR TM engages UniCAR T cells even for an efficient lysis of cancer cells expressing low levels of EGFR. The gene discussed is EGFR; the disease is neoplasm.