Five of these six significant genes shared by Cancer/control and Family/control pairs presented in Figures 2 and 3, in addition to other genes play significant roles in cancer development or tumorigenesis (e.g. MLH3, MSH2, MSH6, SEPT9, GNAS, SLC2A1/GLUT1andSLC2A3/GLUT) [20–22]. The gene discussed is MLH3; the disease is cancer.