Supplementary Table 4 lists top 10 hypo-methylated DMRs for Family/control, and the related genes are SLC2A3, LOC338817,SLC2A1 (GLUT1), METTL16, SEPT9, MEG3, HMHA1, HOXB6, CPOX, and SLC2A3 (GLUT3) (genes underlined are overlapping with genes found for the Cancer/control pair in Table 4). Interestingly, among those top 10 hyper- and hypo- methylated genes, several of them are overlapping with those in Cancer/control pair, including PCNXL3, TONSL, NLGN2, GNAS, MIR3648, SLC2A3 (GLUT3) and SLC2A1 (GLUT1). The gene discussed is NLGN2; the disease is cancer.