Table 3 lists the top 10 most significant hyper-methylated DMRs (distance to transcription start site [TSS] were from -1,000 to +1,000 base-pair [bp] DNA) for Cancer/control pair, and the annotated genes are PCNXL3, MIR4285, NLGN2, MIR3648, HOXA4, CLDN23, TONSL, GNAS, TUBB8 and MIR1247. Table 4 lists the top 10 most significant hypo-methylated DMRs for Cancer/control pair (Distance to TSS are from -1,000 to +1,000 bp). This evidence concerns the gene GNAS and cancer.