Top 10 hyper-methylated DMRs for Family/control pair are listed in Supplementary Table 3, the annotated genes are PCNXL3, RFPL2, LOC729176,TONSL, NLGN2, GNAS, TPRX1, EGFLAM, PRKAR1B, and MIR3648 (genes underlined are overlapping with genes found for the Cancer/control pair in Table 3). The gene discussed is TONSL; the disease is cancer.