SAR was significantly associated with age (all groups), gender (stage III RC), CEA level (stage I/II RC), histological type (stage III CRC), tumor depth (CC), nodal status (stage III CC), lymphatic invasion (stage III CRC), adjuvant therapy (stage III RC), recurrence within 1 year (stage III RC), M1b recurrence (stage II/III CRC), liver metastasis (stage II RC), peritoneal metastasis (CC and stage III RC), local recurrence (stage II CC), and treatment after recurrence (all groups) (Table 5). This evidence concerns the gene CEACAM5 and colorectal carcinoma.