PARP1 and acute myeloid leukemia: Moreover, further analyzes of the levels of pro-apoptotic (cleaved Caspase3 and cleaved PARP) proteins by western blot confirmed that UCN-01 induces apoptosis in a dose dependent manner primarily in MV4:11 and AML#29 cells but not in HL60 and AML#31 cells (Figure 5C).