We investigated the co-occurrence of PAK5 alterations with the three most common melanoma drivers: BRAF, NRAS, and NF1. While PAK5 alterations were randomly distributed across both BRAF- and NRAS-mutant melanomas (p = 0.20 and 0.30, respectively), these alterations were significantly enriched in NF1-mutant tumors (p = 0.01; Supplementary Figure 1B, 1C). Here, NRAS is linked to melanoma.