We found that, indeed, C36L1 significantly increased the levels of CD4+ T cells from 6.86 to 13.35%, CD8+ cytotoxic T cells from 6.11 to 17.6%, and NK1.1+ natural killer (NK) cells from 8.44 to 16.13%, in lung metastatic melanoma (Figure 1E; Figure S6A in Supplementary Material). This evidence concerns the gene CD4 and metastatic melanoma.