Rarer cases of ALS are caused by mutations in the genes encoding TANK-binding kinase-1 (TBK-1) (20), valosin containing protein (VCP) (21), ubiquilin-2 (22), cyclin-F (23), and optineurin (2), as well as several others (Table 1). The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.