While in S. flexneri-infected cells, S6K1 and 4EBP1, two major targets of mTOR, are downregulated, and mTORC1 dispersed in the cytosol throughout infection, during the infection with S. typhimurium, this is observed only in early time-points, suggesting that this bacterial pathogen developed means to manipulate mTOR signaling to favor its intracellular survival (94) (Figure 7). The gene discussed is EIF4EBP1; the disease is infection.